Lab Testing

1) ORDER HERE Metabolic Panel

Includes Kryptopyrrole Urinary Quantitative, Copper Serum, Zinc Plasma and Whole Blood Histamine

2) ORDER HERE Metabolic Panel Plus

Includes Kryptopyrrole Urinary Quantitative, Copper Serum, Zinc Plasma, Whole Blood Histamine and Ceruloplasmin.

3) ORDER HERE Advanced Metabolic Panel

Includes Kryptopyrrole Urinary Quantitative, Copper Serum, Zinc Plasma, Whole Blood Histamine, Ceruloplasmin, Vitamin D, TSH, and CMP14. The Advanced Metabolic Panel aids the practitioner in assessing levels of nutrients that are critical to brain health and in calculating free copper/oxidative stress. The Advanced Metabolic Pan


el identifies imbalances that have been associated with Autism, Aspergers syndrome, ADD/HD, anxiety, Bipolar disorder, assaultive/aggressive/violent behavior, other mental and emotional conditions and schizophrenia. The Kryptopyrrole Urinary Quantitative is an at-home collection kit. The at-home Kryptopyrrole collection kit includes all collection materials shipped to you, overnight return shipping back to our laboratory, running the test, reporting the results, and a receipt for services rendered that you can submit for insurance reimbursement.

The Whole Blood Histamine, Copper Serum, Zinc plasma, Ceruloplasmin, Vitamin D, TSH, and CMP14 will require a blood draw. We will provide the patient with several patient service centers centrally located around the shipping address, instructions, and a laboratory requisition. The patient service center will handle the specimen collection to the requirements of our laboratory. These specimen collection requirements and methodologies are unique. They were modeled by the Original Pfeiffer Treatment Center, Founded by Dr. William J. Walsh. Performing specimen collections to these specifications will allow doctors and patients to have more accurate result that can be placed into personalized optimal functional ranges. We demand only the best specimen collection and transportation available. All of our orders include extensive and award winning customer service.

4) ORDER HERE Advanced Metabolic Panel Plus

Includes Kryptopyrrole Urinary Quantitative, Copper Serum, Zinc Plasma, Whole Blood Histamine, Ceruloplasmin, Vitamin D, TSH, CMP14, and Homocysteine.

5) ORDER HERE General Wellness Panel

The General Wellness Panel is a low cost comprehensive series of laboratory tests. This panel was developed by working hand in hand with medical practitioners who practice preventative care and promote overall well-being for their patients.

Panel Includes:

CMP14, CBC, Lipid Panel, LDH, GGT, Iron, Uric Acid, Glucose

6) ORDER HERE Copper Serum

Copper serum is a highly reliable blood test that directly relates to brain chemistry. Elevated copper levels can alter the brains function, specifically the activity of dopamine and norepinephrine. Copper plays a large role in the metabolism of dopamine and the synthesis of norepinephrine. In turn, elevated copper levels lower dopamine levels and raise levels of norepinephrine. Imbalances in these essential brain chemicals have been related to paranoid schizophrenia, bi-polar disorder, postpartum depression, ADD, ADHD, autism, and violent aggressive behavior or rage. Copper serum levels can single handedly be the root cause of an individual condition, but elevated copper serum levels are also known to cause zinc levels to deplete and oxidative stress to rise.

7) ORDER HERE Zinc Plasma

William J. Walsh PhD., Nutrient Power: Heal your Biochemistry and Heal your Brain

  • Zinc is a trace metal essential to all forms of life.
  • Zinc Plasma is the gold standard of zinc Measure
  • Enhances resistance to stress and helps maintain intellectual function, memory and mood levels.
  • More than 90% of persons diagnosed with depression, behavioral disorder, ADHD, autism and schizophrenia exhibit depleted zinc levels.
  • Zinc deficiency has been associated with delayed growth, temper control problems, poor immune function, depression, poor wound healing, epilepsy, anxiety, neurodegenerative disorders, hormone imbalances and learning problems.
  • Zinc plasma and pyrrole levels coordinate. It has been clinically documented that low zinc levels can cause pyrrole levels to appear underrepresented.

8) ORDER HERE Histamine, Whole Blood

Whole Blood histamine levels are used as a marker for methylation status, and to determine the presence of histadelia, or histapenia. Histamine, in its whole blood form, is utilized as an accurate marker for under methylation or over methylation.

Elevated whole blood histamine levels indicate under-methylation. Review of symptoms and medical history can bolster the diagnosis. For example, most under-methylated persons exhibit seasonal allergies, perfectionism, strong wills, slenderness, OCD tendencies, high libido, depression.

Low whole blood histamine levels indicate over-methylation. Persons who are over-methylated generally exhibit high anxiety, panic disorders, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI’s, etc.

Conditions associated with under-methylation are: Anorexia, Bulimia, shopping/gambling disorders, depression, schizo-affective disorder, delusions, oppositional-defiant disorder, OCD.

Conditions associated with over-methylation are: Anxiety/Panic disorders, anxious depression, hyperactivity, learning disabilities, low motivation, paranoid schizophrenia, hallucinations. (Oct 3, 2003) Most persons with depression, oppositional defiant disorder, OCD, bipolar disorder, or schizophrenia exhibit a genetic abnormality in methylation which appears to be central to their illness. Carl Pfeiffer, MD, PhD of Princeton, NJ was a pioneer in this field. (Oct 3, 2003)

Trained physicians will often order the Methylation Profile (SAM/SAH ratio) test to reinforce whole blood histamine results.

9) ORDER HERE Ceruloplasmin

Ceruloplasmin is used in the evaluation of oxidative stress. When paired with copper, it is used to calculate free copper. When paired with other blood or urine copper tests, ceruloplasmin is used to help diagnose Wilson’s disease. This is due to a decreased ability to incorporate copper into apoceruloplasmin. In turn, free copper levels in plasma and tissue are greatly increased, especially in the liver and brain.

An estimated 95% of copper in the blood is bound to ceruloplasmin.  As a result, only a very small amount of copper is found in the blood in an unbound or free state.

Ordered due to:

  • Jaundice
  • Fatigue
  • Tremors
  • Difficulty walking or swallowing
  • Abdominal pain
  • Anemia
  • Calculation of free copper

Ceruloplasmin levels are not diagnostic, therefore they are commonly ordered and evaluated with copper tests. Often elevated when an individual has a severe infection, tissue damage, inflammation, or certain forms of cancer.

Other causes for an elevated result are:

  • Pregnancy
  • Use of estrogen
  • Use of oral contraceptives
  • Medications such as carbamazepine, phenobarbital, and valproic acid

High levels are linked to a variety of neoplastic and inflammatory states.  Increases are found with carcinomas, leukemias, Hodgkin’s disease, and rheumatoid arthritis.

Low levels are found with protein loss including nephrotic syndromes, malabsorption, and certain forms of liver disease.

10) ORDER HERE Vitamin D 25-Hydroxy
Highly important for your immune health.

11) ORDER HERE  Homocysteine

Homocysteine is ordered for a variety of clinical purposes including heart conditions, and vitamin b12 or folate deficiency. Testing homocysteine can be effective in identifying abnormal levels of B12 and folate before symptoms are present. Practitioners will order this test on patients who may be malnourished or with poor nutrition.  This includes the elderly, drug addicts, and alcohol addicts.

Individuals who are at risk of, or have a family history of heart disease or stroke are also strong candidates for the this test. Practitioners will also order this test on patients with a family history of coronary artery disease. Young children and babies are tested for homocysteine if they test positive for homocystinuria (high levels of methionine) during routine screenings.

Symptoms that qualify a patient to have a homocysteine test include but are not limited to:

  • Fatigue
  • Weakness
  • Diarrhea
  • Dizziness
  • Rapid heart rate
  • Sore mouth/tongue
  • Discomfort in the arms, feet, hands, or legs
  • Loss of appetite

Practitioners order this test on patients who have recently experienced a stroke or heart attack in order to guide treatment.  This is due to the test’s ability to assess an individual’s risk of cardiovascular disease.

Practitioners can also order the homocysteine test on patients over the age of 30 who are going through supplemental treatment.  This allows for the practitioner to assess whether or not certain supplements will have a negative impact on the patient’s heart.

12) ORDER HERE Vitamin B12

Detect B12 deficiency as in pernicious anemia; diagnose folic acid deficiency; evaluate hypersegmentation of granulocyte nuclei; follow up MCV >100; diagnose macrocytic anemia; diagnose megaloblastic anemia; evaluate alcoholism, prenatal care; evaluate malabsorption, neurological disorders, or the elevation of B12 as seen in liver cell damage or myeloid leukemia.

13) ORDER HERE Kryptopyrrole Quantitative Urine

Pyroluria is characterized by elevated urine Kryptopyrrole levels, which result in a dramatic deficiency of zinc and vitamin B6. A high Kryptopyrrole result is also known as pyroluria, pyrrole disorder, or elevated pyrroles. If you do not have a practitioner that will order this testing for you, you can order this test directly through our website.

Our laboratory will provide you with the most accurate Kryptopyrrole result on the market. We are the only laboratory in the U.S.A. that provides a corrected Kryptopyrrole result. Our corrected result accounts for the concentration or dilution of the urine specimen. For example, if the patient has consumed a large amount of water prior to collection, the pyrrole levels will be lower in the initial result. This is due to the fact that the specimen is diluted. DHA Laboratory performs a validated procedure that calculates the level of dilution. Our procedure allows us to compensate for dilution (or concentration) in the corrected result. This allows our patients to have an accurate pyrrole result regardless of the concentration of the urine specimen. Due to the calculation we perform, patients only need to collect a one-time urine collection.

Symptoms Relating to Pyroluria Include:

  • Poor tolerance to physical / emotional stress
  • Poor anger control
  • Emotional mood swings
  • Poor short-term memory
  • Frequent infections
  • Inability to tan
  • Poor dream recall
  • Abnormal fat distribution
  • Sensitivity to light and sound
  • Tactile sensitivities

Pyroluria is Frequently Identified in:

  • Behavior disorders
  • Autism
  • Asperger’s
  • ADHD
  • ADD
  • Depression
  • Assaultive / Aggressive / Violent Behavior
  • Schizophrenia

The Kryptopyrrole test kit is an at home urine collection kit. Our kit contains a stabilizing agent used to stop the deterioration of pyrroles, also known as HPL. The specimen must be frozen and shipped according to our directions. Specimen quality is extremely important for the Kryptopyrrole test. DHA Laboratory takes every measure necessary to ensure the integrity of each Kryptopyrrole specimen.

Treatment of Pyroluria:

Treatment consists of a replacement of zinc and vitamin B6. Because treatment is metabolic rather than pharmacologic, it needs to be focused towards each patient’s individual requirements. Age, weight, symptoms, test results, along with several other factors are always taken into consideration when developing a treatment protocol. Both zinc and vitamin B6 supplementation needs to be directed by a trained physician. Too high of a supplement dosage can be toxic to the body, the wrong form will be ineffective, and certain competing minerals and supplements may have to be avoided.

What’s Included in Your Test Kit Price:

  • Test kit instructions
  • All collection materials
  • Overnight FedEx return shipping label with shipping bag
  • Running of the test
  • Reporting of the results
  • A final receipt for services rendered to submit for insurance reimbursement

Patient Preparation:

Do not collect the first morning urine specimen. A second morning urine collection is preferred, but not required. Supplements containing vitamins or minerals should be stopped 12-24 hours prior to your urine collection. Antibiotics may cause an interfering substance and create a result that cannot be reported. However, do not go off any prescription medications unless advised by your ordering physician.