Category Archives: Gut health

Categories Gut health, Health

Phospholipid Colostrum

Allergy Research Phospholipid Colostrum is obtained from healthy, grass-fed cows, within the first 16 hours after birthing. It has an added natural phospholipid coating (liposomal) from sunflower lecithin, for enhanced protection, dissolution, and absorption.
* It is tested to be free of antibiotics and growth hormones.

Women who are pregnant, wishing to become pregnant, or breastfeeding should use only under the supervision of a qualified healthcare practitioner.

Store in a cool, dry place, tightly capped.

 
Servings Per Container: 60

As a dietary supplement, 1 scoop (5 g) one or two times daily, or as directed by a healthcare professional.


Serving Size: 1 scoop (5 g)

Amount Per Serving
Calories … 50
Protein … 3g
Calcium … 25mg
Colostrum and Sunflower Lecithin Phospholipids … 5g
Immunoglobulins … 1g
(Total)
Proline-Rich Polypeptides … 200mg
(PRP)
Lactoferrin … 50mg

 


Quantity



Inflammation

Science is showing that chronic inflammation is at the root of nearly every disease.  Inflammation is linked to everything from metabolic disorders, like obesity and diabetes, to neurodegenerative diseases and cancer.

How Does Colostrum Work?
Colostrum is highly beneficial in the unique manner in which it provides the body with its numerous immune and growth factors. Most infectious disease-causing organisms enter the body through the mucous membranes of the intestinal tract.. In order to remain healthy, it is critical that we are able to combat disease-causing organisms, such as bacteria and viruses or as well as environmental toxins, contaminants and allergens where they attack us.

Clinical research by Dr. David Tyrell in England, published in 1981, revealed that a high percentage of the antibodies and immunoglobulins present in colostrum are believed not to be absorbed but remain in the intestinal tract where they attack disease-causing organisms before they can penetrate the body and cause disease. The remainder are absorbed and distributed to assist in our internal defense processes. It is this combination of action that makes colostrum so unique and effective as an oral supplement.

Healing the gut
Another critical action of colostrum’s growth factors, epithelial growth factor (EGF) in particular, is to heal and prevent damage to the lining of the gastrointestinal tract by maintaining integrity of tight junctions. The delicate lining between the GI tract and the bloodstream is one cell thick and, because it is permeable, it allows nutrients from food to gain access to the body.

The downside is that the lining can become hyperpermeable when the tight junctions loosen. This condition, commonly referred to as “leaky gut syndrome” or “leaky gut,” allows larger, partially digested food proteins, disease-causing microbes and toxins to enter the body as well. Once inside the bloodstream, the immune system recognizes these substances as foreign and mounts an inflammatory response against them. If the ensuing inflammation becomes chronic, the immune system may mistakenly attack healthy cells, which over time can lead to tissue destruction and autoimmune conditions.

Damage to the gut lining can be caused by a variety of factors, including NSAIDs, prescription pain medications, antibiotics, birth control pills, glyphosate, GMOs, poor lifestyle choices  i.e., chronic alcohol use and environmental toxins. Damage can be compounded by an unhealthy microbiome in which beneficial bacteria are unable to keep pathogenic bacteria in check.

Colostrum’s immunoglobulins, antibodies, lactoferrin and other immune-modulating components can help maintain a healthy microbiome.  When the GI lining is strong and the microbiome is healthy, the body can make good use of the foods and nutrients consumed and help maintain an optimally functioning immune system. Bovine colostrum is the only natural substance that has been clinically proven to heal damage to the intestinal lining and prevent intestinal hyperpermeability.

Reduce inflammation
Bovine colostrum contains more than 200 growth factors and immune-modulating components (such as the aforementioned PRPs) that function synergistically to help the immune system do its job more effectively.  PRPs can stimulate an underactive immune system to seek out and destroy viruses and bacteria to prevent infection. They can also tone down an overactive immune system, such as in the case of autoimmune conditions, to prevent further damage caused by excessive inflammation.

Note that when prescribing bovine colostrum as an adjunct therapy, for it to be effective its healing components must be bioavailable. The infant’s digestive system does not contain harsh stomach acids the way an adult’s digestive system does. The immature GI tract plus the natural lipid coating on mother’s colostrum guarantees maximum benefit for the infant.

But when raw, fresh bovine colostrum is processed into powder form, it loses the lipid coating that otherwise protects it from being digested in the adult’s stomach, and it becomes more like powdered milk. Thus, it is critical that the lipid coating be restored. The reapplication of lipids preserves the growth factors and immune-modulating components, making it as close to raw, fresh colostrum as possible.

Colostrum Meets the Microbiome A Tried and True Remedy for Gut Health Takes Centre Stage

The microbiome is one of the most exciting discoveries of 21st century biomedicine, and scientific heavyweights as prominent as Craig Ventner, whose company sequenced the human genome, are now sequencing the microbiome.

The microbiome is the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space–the mass of trillions of microbes that live on and in your body. Most of them are in your large intestine, but they thrive in your mouth, on your skin, and even in your bloodstream.

The human gut contains on average: 40,000 bacterial species, 9 million unique bacterial genes and 100 trillion microbial cells. These hundred trillion microbes render us a walking, breathing ecosystem–more microbe than man.

Research on ancient and modern microbiomes is uncovering new insights into the fluid and ever-changing composition of our resident bacteria. An intact “microbial tomb” was found on teeth from humans buried in Pompei over a thousand years ago. Fossilized fecal samples from medieval times are being analyzed, and scientists are even going to sequence the microbiomes of identical twin astronauts up in space, to see how low gravity and diet might affect it.

The Human Food Project in Tanzania is sampling the gut microbiome of hundreds of Hadzabe hunter-gatherers, whose diet is so different than that of most individuals in developed nations.

Why such interest in the microbiome? Because the microbes we cohabit with, particularly those of the gut, help regulate human health and wellbeing, and even influence the brain, neurological function, and behavior. New research shows that beneficial bacteria in our microbiome may help us fight infection anywhere in the body. In fact, gut microbes help our bodies develop immune

And that brings us to colostrum: Mother Nature’s first food for the developing microbiome in all mammals, our earliest and most potent influence on gut health and bacterial composition.

Colostrum provides a cornucopia of nutrients, immunoglobulins, passive antibodies, and signaling peptides that Mother Nature has perfectly honed to protect the newborn infant from infection, and to help train and shape the emerging immune system so it can handle its environment. Ingesting colostrum establishes beneficial bacteria in the neonate’s digestive tract.

“Research shows that colostrum can restore a leaky gut lining to normal permeability levels, and reduce movement of toxins and gut microbes into the bloodstream.”

Colostrum contains immunoglobulins such as IgG, IgA, IgM; the immune modulating molecule lactoferrin; fat-soluble vitamins including retinol, tocopherol, and beta-carotene; water soluble vitamins including niacin, thiamine, riboflavin, vitamin B12, pyridoxal, pyridoxamine, and pyridoxine; and minerals such as calcium, potassium, magnesium, sodium, zinc, iron, copper and manganese.

It contains whey proteins, oligosaccharides, immunoglobulins, growth factors including IGF-1, IGF-2, TGFbeta and EGF, prolactin, and insulin. Fresh colostrum also contains both essential and non-essential amino acids, enzymes, and commensal bacteria such as Lactobacillus acidophilus and Bifidobacterium. Finally, colostrum contains a rich array of novel, potent signaling peptides called proline-rich peptides (PRPs).

Colostrum helps the newborn gut develop a healthy microbiota. When our gut ecology becomes imbalanced, we experience dysbiosis. Then the delicate gut lining and associated lymphoid tissue becomes inflamed, leading to altered levels of permeability.

That increased permeability can then result in microbial translocation–or the movement of toxins and gut microbes through the normally tight epithelial barrier of the gastrointestinal tract into the bloodstream. Microbial translocation has been implicated in the pathogenesis of HIV, cirrhosis, atopic dermatitis and many other conditions.

Decreased permeability can lead to altered absorption of essential food components, a thickening of the lining, loss of the local villi and subsequent activation of the innate lymphoid cell, as bacteria have direct contact to the lining because of loss or decreased functionality of the mucus layer.

Research shows that colostrum can restore a leaky gut lining to normal permeability levels. The immunoglobulins in colostrum are especially impressive at combating gut pathogens, including H. pylori, E. coli and protozoan parasites and amoebas. Antimicrobial effects are likely due to the presence of the antibody (immunoglobulin) complement system.

In addition, research by David Tyrell, MD, in 1980, suggested that a high percentage of antibodies and immunoglobulins present in colostrum remain in the intestinal tract, where they attack pathogens.

A recent study on bovine colostrum suggested that it is a potential source of anti-infective glycans which might limit Campylobacter jejuni infection, the leading cause of acute bacterial infectious diarrhea in humans. Researchers found that bovine colostrum dramatically reduced the cellular invasion and translocation of C. jejuni, in a concentration dependent manner. Bovine colostrum also completely prevented C. jejuni binding to chicken intestinal mucin, in vitro.

Bovine colostrum can restore the damage caused by anti-inflammatory drugs (NSAIDs) to the gut lining. For instance, the anti-inflammatory NSAID indomethacin when used alone causes a three-fold increase in gut permeability. But when taken with colostrum by healthy volunteers, there is no increase in gut permeability. Researchers concluded that bovine colostrum may provide a novel approach to the prevention of NSAID induced gastrointestinal damage in humans.

In another study, researchers determined that bovine colostrum is a rich source of tissue repair and growth factors, and limits gastrointestinal injury. Feeding with colostrum facilitated growth of the intestinal villi, assisting with the restoration of barriers that have become impermeable as well as too permeable. Only the colostrum casein fraction stimulated intestinal villus elongation, whereas the whey fraction and mature milk casein showed no such effect. Colostrum has therapeutic potential for intestinal inflammation.

“New research shows that beneficial bacteria in our microbiome may help us fight infection anywhere in the body.”

Colostrum enemas were effective in the treatment of distal colitis during a randomized, double-blind study. Fourteen patients with a mean age of 45 and mild to moderately severe distal colitis, were given colostrum enema or placebo enema for 4 weeks. Both groups also received the drug mesalazine.

The colostrum group showed a mean reduction in symptom score of 2.9, while the group only on medication showed an increase of 0.5. Symptoms improved in five of the eight patients in the colostrum group and in two of the six patients in the placebo group. The researchers concluded that bovine colostrum enemas may be a novel adjunctive therapy for left-sided colitis along with standard treatment with anti-inflammatory drugs such as mesalazine.

Lactoferrin is one of the main proteins in colostrum. High quality supplemental colostrum has over 1%. Lactoferrin binds free iron, which many bacteria and fungi need to reproduce. Lactoferrin can penetrate the cell wall of bacteria, which allows an antimicrobial enzyme in gastric secretions calls lysozyme to then enter the cell and cause it to burst. Together, lactoferrin and lysozyme can destroy Candida albicans.

We know that nutrients are absorbed along the length of the small intestine, which is lined with millions of microscopic, finger-like projections called villi. Each villus is connected to a mesh of capillaries so that nutrients can pass into the bloodstream.

Colostrum extract that contains bioactive components such as insulin-like growth factor-I (IGF-I), enhances intestinal villus size and can modulate neonatal gastrointestinal tract development and function. Villus circumference and height in the small intestine, as well as epithelial cell proliferation, are higher in calves fed colostrum extract than in controls.

According to a review article in 2011 on colostrum, a commercial product which is made from large standardized pools of colostrum collected from over 100 cows has been used to treat a number of diseases, including diarrhea caused by diarrheagenic E. coli. Bovine colostrum contains significant antimicrobial properties as a result of natural exposure of the cows to antigens of pathogens that may afflict humans as well.

All colostrum and milk will contain some secretory IgA. The presence of secretory IgA in the intestinal lumen is part of the protective function of  the epithelial barrier in the intestine and also plays an important role in maintaining ecological tolerance with the commensal bacteria.

Milk and colostrum secretory IgA in the intestine will bind bacteria, toxins and other macromolecules, limiting their ability to bind to intestinal cells and thereby be transported through the mucosa to cause a systemic immune response. The mature stomach lining of an adult is of course more effective in digesting proteins and peptides than that of a newborn infant.

Fresh bovine colostrum has a natural phospholipid coating that enhances its properties, but this is lost during the processing of colostrum into a powder form. New research by biochemist Michail Borissenko, BSc, MSc, chief scientist at the Institute of Colostrum Research in New Zealand, suggests that coating bovine colostrum with high quality phospholipids during processing helps to make it more soluble and preserve it until it reaches the large intestine.

Although bovine colostrum is generally well tolerated, colostrum with the phospholipid coating restored may possibly increase tolerance and benefit for sensitive individuals. Colostrum and phospholipids together might provide an ideal and stable source of the ultimate “mother’s milk” for healing the gut and restoring a healthy microbiome.

error: Content is protected !!